Thermal-Transfer Printing: A Better Way to Print Library Labels

Thermal-transfer printing, a technology borrowed from the manufacturing sector, offers libraries a flexible method for printing durable, accurate, legible, and attractive labels that reliably adhere to most book surfaces. When guided by an electronic program customized to meet a library’s particular needs, a thermal-transfer printing system offers virtually limitless variations in font, format, and functionality. It can print labels directly from the online catalog, thereby guaranteeing that call numbers on labels match what patrons see in the catalog. This article explains thermal-transfer printing and how it compares with other printing technologies, briefly explores applications in both the manufacturing and library environments, and describes in detail how Utah State University Libraries and a few other libraries use it to improve the accuracy, appearance, and durability of their spine labels

The NSF/NIH Effect: Surveying the Effect of Data Management Requirements on Faculty, Sponsored Programs, and Institutional Repositories

The scholarly communication landscape is rapidly changing and nowhere is this more evident than in the field of data management. Mandates by major funding agencies, further expanded by executive order and pending legislation in 2013, require many research grant applicants to provide data management plans for preserving and making their research data openly available. However, do faculty researchers have the requisite skill sets and are their institutions providing the necessary infrastructure to comply with these mandates? To answer these questions, three groups were surveyed in 2012: research and teaching faculty, sponsored programs office staff, and institutional repository librarians. Survey results indicate that while faculty desire to share their data, they often lack the skills to do this effectively. Similarly, while repository managers and sponsored programs offices often provide the necessary infrastructure and knowledge, these resources are not being promoted effectively to faculty. The study offers important insights about services academic libraries can provide to support faculty in their data management efforts: providing tools for sharing research data; assisting with describing, finding, or accessing research data; providing information on copyright and ownership issues associated with data sets; and assisting with writing data management plans

Western States Dublin Core Metadata Best Practices, version 1.2

Funded by a grant awarded by the Institute for Museum and Library Services (IMLS) in the fall of 2001, the University of Denver (Denver, Colorado) spearheaded a multi-state collaborative initiative to create a virtual collection of widely dispersed digital resources on the topic, Western trails. As part of this initiative, 23 institutions in four Western states were awarded mini-grants to create digital content and metadata for resources related to Western trails. In addition to creation of a virtual collection of digital resources, another significant component of this multi-state initiative was development of a set of Dublin-Core based best practices by representatives from cultural heritage institutions beyond the original four participating states. Accordingly, in March 2002, 18 representatives from eight Western states met in Denver, Colorado to begin exploring issues associated with application of Dublin Core to digital objects by cultural heritage institutions. This group, the Western States Digital Standards Group (WSDSG) Metadata Working Group, formed two task forces to develop guidelines for the Dublin Core metadata. The WSDSG Metadata Working Group met again in Topeka, Kansas in July 2002 to finalize the guidelines and determine the remaining components of a best practices document. In November 2002 the resultant WSDSG Guidelines for the Dublin Core Elements were posted on the Colorado Digitization Program (CDP) and the Western Trails project website. In January 2003, the WSDSG Best Practices document will be released. This Best Practices document is based upon and supercedes the CDP’s General Guidelines for Descriptive Metadata Creation and Metadata

Letter of Information

Letter of Information for participants in the study: The Impact of New Data Management Plan Requirements on Faculty, Sponsored Programs, and Institutional Repository Managers

Tools for Using and Organizing Online Resources to Enhance Reference and Instruction

Presentation at the 2010 Utah Library Association annual conference. This presentation addressed different tools that can be used to incorporate technology and online resources into teaching and instruction

Evaluation of a multi-disciplinary back pain rehabilitation programme—individual and group perspectives

To evaluate the impact of a multi-disciplinary back pain rehabilitation programme using a combination of individual and group change data. A total of 261 consecutive patients attending an assessment session for the back pain rehabilitation programme completed the SF-36 health survey questionnaire. The patients were requested to complete the questionnaires again at programme completion and at the 6-month follow-up. The Reliable Change Index was used to define 'clinical significance' in terms of the assessment of individual change. Half of those patients considered to be suitable for the programme subsequently completed it. In group terms, non-completers scored lower than completers on all SF-36 scales. Statistically significant improvements were evident for those completing the programme (all scales at P < 0.000), with improvement maintained at follow-up. In individual terms, 'clinical significance' was exceeded most frequently in the Physical Functioning and Role Physical scales. Whilst some participants lost previous improvements between completion and follow-up, others improved over this same time period. The majority of those completing the programme showed improvement in at least one scale. Adding assessment of individual change to traditional group change measures provides greater insight into the impact a rehabilitation programme has upon participants' quality of life. Whilst the programme is clearly effective for those who complete it, work is required to limit post-programme deterioration and improve uptak

The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines

<p>Abstract</p> <p>Background</p> <p>Curcumin is a naturally occurring phenolic compound shown to have a wide variety of antitumor activities; however, it does not attain sufficient blood levels to do so when ingested. Using structure-based design, a novel compound, FLLL32, was generated from curcumin. FLLL32 possesses superior biochemical properties and more specifically targets STAT3, a transcription factor important in tumor cell survival, proliferation, metastasis, and chemotherapy resistance. In our previous work, we found that several canine and human osteosarcoma (OSA) cell lines, but not normal osteoblasts, exhibit constitutive phosphorylation of STAT3. Compared to curcumin, we hypothesized that FLLL32 would be more efficient at inhibiting STAT3 function in OSA cells and that this would result in enhanced downregulation of STAT3 transcriptional targets and subsequent death of OSA cells.</p> <p>Methods</p> <p>Human and canine OSA cells were treated with vehicle, curcumin, or FLLL32 and the effects on proliferation (CyQUANT^®), apoptosis (SensoLyte^®Homogeneous AMC Caspase- 3/7 Assay kit, western blotting), STAT3 DNA binding (EMSA), and vascular endothelial growth factor (VEGF), survivin, and matrix metalloproteinase-2 (MMP2) expression (RT-PCR, western blotting) were measured. STAT3 expression was measured by RT-PCR, qRT- PCR, and western blotting.</p> <p>Results</p> <p>Our data showed that FLLL32 decreased STAT3 DNA binding by EMSA. FLLL32 promoted loss of cell proliferation at lower concentrations than curcumin leading to caspase-3- dependent apoptosis, as evidenced by PARP cleavage and increased caspase 3/7 activity; this could be inhibited by treatment with the pan-caspase inhibitor Z-VAD-FMK. Treatment of OSA cells with FLLL32 decreased expression of survivin, VEGF, and MMP2 at both mRNA and protein levels with concurrent decreases in phosphorylated and total STAT3; this loss of total STAT3 occurred, in part, via the ubiquitin-proteasome pathway.</p> <p>Conclusions</p> <p>These data demonstrate that the novel curcumin analog FLLL32 has biologic activity against OSA cell lines through inhibition of STAT3 function and expression. Future work with FLLL32 will define the therapeutic potential of this compound <it>in vivo</it>.</p

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Schizophrenia has a heritability of 60-80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies